The short interfering RNA (siRNA) agent SLN360 was well tolerated and lowered lipoprotein(a) by up to 98% in volunteers without cardiovascular disease but with elevated Lp(a) in the small dose-ranging APOLLO trial. Following a single subcutaneous dose of SLN360 (Silence Therapeutics), there was a dose-dependent reduction in Lp(a) plasma levels by a median of 46%, […]
Conference News
The drug-coated balloon (DCB) for peripheral interventions had its share of troubles in recent years before making a comeback, with the field of available devices perhaps even poised for expansion. In a randomized trial, an investigational paclitaxel-coated DCB with both a quirky design and confectionery name achieved achieved better patency outcomes in femoropopliteal lesions, with […]
Conference News
NICE, France ― New therapeutic approaches have emerged for preventing diabetic foot ulcers and promoting their healing. Endocrinologist and diabetes specialist Olivier Bourron, MD, of the Pitié-Salpêtrière Hospital in Paris, described these approaches at the 48th annual congress of the Francophone Diabetes Society. A Common Complication Unlike macroangiopathic complications (such as ischemic heart disease and […]
Conference News
In a randomized trial of patients with angina and no obstructive Coronary artery disease(ANOCA), 6 weeks of treatment with diltiazem did not improve coronary vasomotor dysfunction — apart from epicardial spasm — or angina symptoms and quality of life. The trial investigated whether this therapy would improve these outcomes in patients with two endotypes of […]
Conference News
Pregnant women with even mild hypertension should receive blood pressure–lowering medications to reduce the likelihood of adverse outcomes for the mother and the child, according to a large, open-label, randomized trial. “Treating to the blood pressure goal in this study reduced the risk of adverse events associated with pregnancy but did not impair fetal growth,” […]
Conference News
A low-sodium diet was not associated with a reduction in future clinical events in a new study in ambulatory patients with Heart Failure. But there was a moderate benefit on quality of life and New York Heart Association (NYHA) functional class. The results of the SODIUM-HF trial were presented today at the American college of […]
Conference News